Isaacs Hotel is located approximately one mile from Grafton Street, two miles from Dublin Castle, and six miles from Dublin Airport.

The hotel restaurant, Il Vignardo, has a unique decor and serves Italian food with a fine selection of wines. Le Monde is a cafe-style bar that serves specialty coffees, wines, and lunches, along with a full bar. The hotel also offers room service.

All rooms feature private bathrooms, TVs, trouser pressers, coffeemakers, irons and ironing boards, hairdryers, dataports, and safes.